Desert Bus for Hope

http://desertbus.org/

Desert Bus for Hope is a charity drive done once a year by Loading Ready Run. All donations are given to Child's Play, a charity that gives terminally ill children gaming equipment (Xbox 360s, PS3s, etc) so that they can game and enjoy themselves in their hospitals.

It is a secular charity and thus there might be some language, but regardless, this is an exceptional cause worth donating to if you can.

Desert Bus is over, but during it's six days, they collected and donated $378,885.01 to Child's Play (it also worth noting that counting all previous Desert Buses, they've donated $821,962.01 to Child's Play).