Although the Bible does not address marijuana directly, it does discuss other mind-altering drugs. Specifically, the Bible addresses the use of drugs in the book of Galatians:
Now the deeds of the flesh are evident, which are: immorality, impurity, sensuality, idolatry, sorcery, enmities, strife, jealousy, outbursts of anger, disputes, dissensions, factions, envying, drunkenness, carousing, and things like these, of which I forewarn you, just as I have forewarned you, that those who practice such things will not inherit the kingdom of God. (Galatians 5:19-21)
So, where are the drugs mentioned in this verse? Actually, the word translated "sorcery" is the Greek word pharmakeia, from which we get the English word "pharmacy." The primary meaning is "the use or the administering of drugs" (usually associated with sorcery or idolatry). Since this verse comes from a list of things that if practiced would preclude one from heaven, this should be a reasonably strong suggestion that the Christian should not practice drug use. In addition, the book of Revelation lists drug use as one of the things for which the unrepentant will suffer the wrath of God.
The Bible has a lot to say about alcohol. At the time, there was no hard (distilled) liquor, just wine and beer (which was more diluted at that time then it is now). Even so, the Bible has much to say about people who used wine to get drunk. One was Lot, who got drunk and slept with his daughters. Others sold girls to get wine to get drunk. The Bible warns about the bad effects of getting drunk - seeing strange sights and being confused, saying stupid things, making poor decisions, vomiting, getting involved in fights, and losing one's wealth. We are warned not to join with those people. The consequences of such behavior is judgment. Jesus Himself used two examples of those who will be drunk when God comes to judge the world. God's judgment of such behavior does not paint a pretty picture. The New Testament condemns drunkenness and warns that those who engage in that behavior will not inherit the kingdom of God (i.e., heaven).
The Old Testament warns the priests not to go into God's house drunk, or they will die. In the New Testament, those who serve in the body of Christ are not to be addicted to wine or any other sordid thing. Even those who do not directly serve in the church are warned not to be addicted to wine. Finally, the New Testament commands us to not get drunk, but be filled with the Spirit of God:
Do not get drunk on wine, which leads to debauchery. Instead, be filled with the Spirit. (Ephesians 5:18)
Does marijuana get one intoxicated? Even proponents of marijuana usage encourage users never to drive a motor vehicle while using marijuana. Why is this? Because when one use marijuana, one is legally intoxicated and incapable of clear thinking and reasonable reactions. Being intoxicated is clearly condemned in scripture. So, if one uses drugs or anything else to escape and get high, or is addicted to these substances, it is against the commands of scripture and inappropriate for Christian participation.